8:50 am Chair’s Opening Remarks

Uncovering the Latest Applications of Genome Editing Tools

9:00 am Disrupting Crop Breeding with Haploid Induction (HI) & Genome Editing (GE)


  • Accelerating genetic gain through HI and DH in cereals
  • Wheat and maize HI, based on CENTROMERIC HISTONE3 (CenH)
  • Using HI for “hit and run” CRISPR to commercial germplasm

9:30 am Unique Genome Editing Opportunities with Cas-CLOVER, A Proven Alternative to Cas9.


  • Cas-CLOVER is a dual guided system that creates double-strand cuts upon dimerization of nuclease Clo051
  • Cas-CLOVER is more precise with less off-target effect and results in larger, sticky-ended overhangs compared to Cas9’s smaller blunt-ended deletions
  • Proven in both dicots and monocots results in tobacco and banana with be presented
  • A new partnership between Demeetra and Agribody provides one-stop shop access to editing a universal genetic switch trait to increase perishable product shelf life

10:00 am ROUND TABLE DISCUSSION: Expanding the Gene Editing Toolbox


As technology advances the opportunities to leverage genome editing continues to expand. As the gene editing “tool box” continues to grow it will be important to understand how this technology can be applied and what this means for the field. As such this session will set out to discuss:

  • Exploring applications of prime and base editing
  • Applications of homology directed repair
  • Can organelle CRISPR technology opens new opportunities in agriculture
  • Exploring new technology that enables gene editing of both mitochondrial and chloroplast DNA

11:00 am
Morning Refreshments & Speed Networking

Navigating an Evolving Global Regulatory Landscape for Genome Edited Crops

12:00 pm Update on Regulatory Requirements Applicable to Genome Editing in Agriculture


  • Current status of updates to the U.S. Coordinated Framework for the Regulation of Biotechnology
  • Regulatory approaches of USDA, FDA, and EPA to genome editing
  • Outlook for future U.S. regulatory improvements
  • Brief discussion of International regulations

12:30 pm Regulating CRISPR Edited Organisms by U.S. Department of Agriculture

  • Subray Hegde Director of Biotechnology Risk Analysis Programs, USDA APHIS


  • Regulatory Exemptions
  • Regulatory Status Review
  • CRISPR Modified Organisms—Trait Modifications and Future Perspectives

1:00 pm
Lunch & Networking

2:00 pm PANEL DISCUSSION: Assessing the Evolving Global Regulatory Landscape for Genome Editing in Agriculture: Is a “Science based & Product Focused” approach possible?

  • Keith Matthews Attorney at Law, Wiley Rein LLP
  • Subray Hegde Director of Biotechnology Risk Analysis Programs, USDA APHIS
  • Dan Jenkins Head of Regulatory, Pairwise Plants LLC
  • Jim Dunwell Professor - Plant Biotechnology, University Of Reading


Guidelines for the implementation of genome edited crops are evolving rapidly at a global scale. As both national and international guidelines threaten to impact trading opportunities and thus commercial potential, it is vital for stakeholders in the space to stay updated and understand where guidelines are likely to move in the near future.

As such this panel will set out to cover topics including:

  • What does a product focused approach to regulatory guideline development look like
  • Why should guidelines regulate the product not the process
  • Current USDA guidelines concerning ‘non-GMO’ status and how this is expected to evolve
  • Standpoints across the international landscape, including Europe, Asia & South America
  • Understanding the regulatory framework for gene edited microbes and microbiome products
  • How does the evolving regulatory landscape at a global scale influence the ability to trade commodity crops across borders?

Improving & Implementing Gene Discovery Tools for Better Target Validation & Identification

3:00 pm Yield10 Trait Development: Target Discovery to Crop Improvement


  • Multi-Plex editing of genes based on synthetic biology approaches to increase seed oil in Camelina, the E3902 line
  • The unmet need – identifying new gene targets for seed oil increases – GRAIN and the C3019-C3022 gene targets
  • Future strategies for combinatorial editing to further increase seed oil content

3:30 pm
Afternoon Refreshments & Networking

4:00 pm Gene editing & Crop Breeding to Develop High Protein Soybeans


  • Amfora is developing two categories of soybeans with increased protein content.
  • Amfora’s core technology is using gene editing to drive increased expression of NF-YC4, which results in a phenotype of increased protein at the expense of carbohydrates.
  • We are using a combination of unique germplasm, modern genomics-based crop breeding and new breeding technologies to develop and commercialize valuable products for food and aquaculture applications.

4:30 pm Creating Consumer Value Using CRISPR: New Products Made Via Highly Multiplexed Editing

  • Ryan Rapp Chief Technology Officer, Pairwise Plants LLC


  • Better understanding consumer traits
  • Leveraging multiplexed gene editing
  • cas12a – opportunities and challenges of use